Dr. Self Mesotherpy article published in JPRAS

Journal of Plastic, Reconstructive & Aesthetic Surgery) pubished Dr. Self's Mesotherapy article (2008 edition 61, pages 1321-1324).

Summary

The aim of this study was to evaluate the lipolytic potential of solutions used in
the practice of cosmetic mesotherapy to stimulate lipolysis, cause local fat reduction and reduce
the appearance of cellulite. The mesotherapy solutions were tested in a human fat cell
assay using the fold induction of glycerol generation as a measure of lipolysis. The following
mesotherapy solutions were tested: aminophylline; yohimbine; isoproterenol; melilotus; aminophylline
with melilotus; aminophylline with isoproterenol; aminophylline with isoproterenol
and yohimbine; aminophylline with isoproterenol and lidocaine; and aminophylline with isoproterenol,
yohimbine and lidocaine. Isoproterenol (P < 0.002), aminophylline (P < 0.00004)
and yohimbine (P < 0.001) stimulated lipolysis compared to the buffer control. The lipolysis
stimulated by melilotus (P < 0.01) and isoproterenol (P < 0.002) was enhanced by aminophylline
(P < 0.001 and P < 0.001, respectively). The lipolytic stimulation by aminophylline and isoproterenol
(P < 0.0009), and by aminophylline and isoproterenol with yohimbine (P < 0.0007)
was inhibited by lidocaine, not significant compared to buffer control for aminophylline and
isoproterenol, but aminophylline, isoproterenol and yohimbine still stimulated lipolysis more
than control, P < 0.05).

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